On Steroidal Sapogenins. IX. Some Derivatives of Metagenin Related to Steroidal Hormones (Part 1)
نویسندگان
چکیده
منابع مشابه
Preliminary pharmacobiological study of new steroidal sapogenins.
The chemotherapeutic study of a limited series of steroidal sapogenins from several endemic species of the flora of the Canary Islands is presented here. On the whole, they possess a very weak antibacterial activity, a slight antifungal effect and one of them, vespertilin, displays interesting cytostatic activity (ID50 = 5 micrograms/ml). A pharmacodynamic screening carried out on this product ...
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14 The mechanisms of sorption of four steroidal hormones – estradiol, estrone, progesterone and 15 testosterone – to electrodialysis (ED) membranes were investigated as a function of solution pH 16 and presence of humic acid (HA). Hormone-membrane partition coefficients (log KAEM/CEM) 17 determined through sorption isotherm experiments suggested that hormone sorption was due to 18 hydrogen bond...
متن کاملEffect of steroidal sapogenins on ruminal fermentation and on production of lactating dairy cows.
Supplementation of dairy rations with steroidal sapogenins was evaluated in an in vitro, an in situ, and a production trial. Sixteen in vitro semicontinuous rumen cultures were supplied a 55:45 concentrate to roughage substrate with Sarsaponin concentrations of 0, 33, 55, and 77 ppm of air-dry feed for 22 d. Supplementation decreased protozoa numbers and increased bacterial numbers and acid det...
متن کاملSynthesis of steroidal thiadiazoles from steroidal ketones.
Syntheses of steroidal heterocycles containing a five-membered N,S- heterocycle attached at the 6,7 positions of the B ring are reported. 5Alpha-cholestane-6-one (1), its 3beta-acetoxy- (2) and 3beta-chloro- (3) analogues reacted with semicarbazide and aqueous sodium acetate in refluxing ethanol to yield 5alpha-cholestan-6-one-semicarbazone 1a and its 3-beta-acetoxy and 3beta-chloro derivatives...
متن کاملDe novo Transcriptome Assembly and the Putative Biosynthetic Pathway of Steroidal Sapogenins of Dioscorea composita
The plant Dioscorea composita has important applications in the medical and energy industries, and can be used for the extraction of steroidal sapogenins (important raw materials for the synthesis of steroidal drugs) and bioethanol production. However, little is known at the genetic level about how sapogenins are biosynthesized in this plant. Using Illumina deep sequencing, 62,341 unigenes were...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1966
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.14.247